期刊
EXPERT REVIEW OF VACCINES
卷 6, 期 5, 页码 835-847出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/14760584.6.5.835
关键词
adjuvant; cytokine; imiquimod; immune response modifier; resiquimod; T helper; Toll-like receptor7; Toll-like receptor 8; vaccine
类别
Synthetic immune response modifiers, such as resiquimod, are Toll-like receptor 7 and 8 agonists that act as vaccine adjuvants, enhancing antigen-specific antibody production and skewing immunity towards a Th 1 response. These compounds stimulate dendritic cells to secrete cytokines, upregulate costimulatory molecule expression and enhance antigen presentation to T cells. The compounds have demonstrated vaccine adjuvant properties in a number of animal models. The adjuvant effects can be enhanced by measures that allow the drug to stay localized with the vaccine without quickly entering the systemic circulation. Clinical studies demonstrate that topical application of resiquimod and analogs is safe and effective at activating the local immune response. For injection, resiquimod or a similar compound may need to be formulated to allow for local immune activation without induction of systemic cytokines.
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