期刊
MAGNETIC RESONANCE IN MEDICINE
卷 58, 期 4, 页码 650-655出版社
WILEY
DOI: 10.1002/mrm.21393
关键词
PARACEST; low B(1)WALTZ-16; contrast; exchange; OPARACHEE
资金
- NCI NIH HHS [CA115531] Funding Source: Medline
- NCRR NIH HHS [RR02584] Funding Source: Medline
- NHLBI NIH HHS [HL 78634] Funding Source: Medline
- NIBIB NIH HHS [EB004582] Funding Source: Medline
In this report, the On resonance PARamagnetic CHemical Exchange Effects (OPARACHEE) method was implemented in vivo using WALTZ-16* as a preparation pulse with a standard spin echo sequence to detect the accumulation and clearance of the TmDOTA-4AmC(-) in mouse kidney. The performance of the technique in vivo is described in terms of the magnitude of the contrast effect versus the bolus agent concentration and Signal-to-noise ratio (SNR) levels. The lowest injected concentration of TmDOTA-4AmC(-), 200 mu L of a 2-mM stock solution (corresponds to similar to 0.2 mM agent in plasma), reduced the total water signal in the kidney papilla by 45% 3 min after the a bolus injection. The results show that the OPARACHEE methodology employing low-amplitude RF trains can detect paramagnetic exchanging agents in vivo.
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