期刊
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
卷 77, 期 4, 页码 676-682出版社
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2007.77.676
关键词
-
资金
- FIC NIH HHS [D43 TW007123-03, D43 TW007123, D43 TW007123-04] Funding Source: Medline
- NIAID NIH HHS [R01 AI053695-04, T32 AI060546, R01 AI053695-01, R01 AI053695-05, T32 AI060546-04, T32 AI 060546, R01 AI053695-03, AI 053695, T32 AI060546-03, R01 AI053695, R01 AI053695-02] Funding Source: Medline
Schistosomiasis mansoni is usually a chronic infection that leads to long-term, systemic exposure to schistosome antigens. Experimental Schistosoma mansoni infection is associated with immunoregulatory mechanisms, including T regulatory cells (Treg) that may help control morbidity and dampen resistance to re-infection. We now show that some schistosomiasis mansoni patients have high proportions of CD3(+)/CD4(+)/CD25(high) Treg. On effective treatment with praziquantel, these high Treg percentages decrease, and fewer of the remaining Treg express CD45RO. The proportion of Treg in S. mansoni-infected patients is inversely related to their percentage of activated, putative effector T cells (CD3(+)/CD4(+)/CD25(medium)/HLA-DR+ cells). We conclude some, but not all, schistosomiasis mansoni patients develop high percentages of circulating Treg, and effective treatment both decreases the levels of these cells and changes their phenotypes, possibly because of the removal of constant exposure to antigens from intravascular, egg-producing adult worms.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据