期刊
ANAESTHESIA
卷 64, 期 2, 页码 147-151出版社
WILEY
DOI: 10.1111/j.1365-2044.2008.05732.x
关键词
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资金
- Department of Anaesthesiology, University of Wurzburg [1518 TG 72]
- Helsinki University Hospital
- Biomedicum Helsinki Foundation [FIN-00029 HUCH]
- Finnish Medical Foundation [FIN-00100]
- Maud Kuistila Foundation [FIN-00101]
- Paulo Foundation [FIN-02231]
- Research Foundation of Orion Corporation [FIN-02200]
- NIH [GM 061655]
- Gheens Foundation
- Joseph Drown Foundation
- Commonwealth of Kentucky Research Challenge Trust Fund
- [TYH 0324]
- [TKK 2120]
- [TKK 3120]
Ondansetron is widely believed to prevent postoperative vomiting more effectively than nausea. We analysed data from 5161 patients undergoing general anaesthesia who were randomly stratified to receive a combination of six interventions, one of which was 4 mg ondansetron vs placebo. For the purpose of this study a 20% difference in the relative risks for the two outcomes was considered clinically relevant. Nausea was reduced from 38% (969/2585) in the control to 28% (715/2576) in the ondansetron group, corresponding to a relative risk of 0.74, or a relative risk reduction of 26%. Vomiting was reduced from 17% (441/2585) to 11% (293/2576), corresponding to a relative risk of 0.67, or a relative risk reduction of 33%. The relative risks of 0.67 and 0.74 were clinically similar and the difference between them did not reach statistical significance. We thus conclude that ondansetron prevents postoperative nausea and postoperative vomiting equally well.
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