期刊
ONCOGENE
卷 26, 期 47, 页码 6803-6815出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1210763
关键词
AMKL; erythroleukemia; myeloproliferative diseases; GATA1; RUNX1; Fli-1; friend virus
资金
- NCI NIH HHS [R01 CA101774-05, R01 CA101774] Funding Source: Medline
Red blood cells and megakaryocytes arise from a common precursor, the megakaryocyte- erythroid progenitor and share many regulators including the transcription factors GATA- 1 and GFI- 1B and signaling molecules such as JAK2 and STAT5. These lineages also share the distinction of being associated with rare, but aggressive malignancies that have very poor prognoses. In this review, we will briefly summarize features of normal development of red blood cells and megakaryocytes and also highlight events that lead to their leukemic transformation. It is clear that much more work needs to be done to improve our understanding of the unique biology of these leukemias and to pave the way for novel targeted therapeutics.
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