期刊
ANAESTHESIA
卷 63, 期 9, 页码 941-947出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2044.2008.05523.x
关键词
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资金
- NIA NIH HHS [R01 AG018772, K24AG00949, R21 AG025193, R01 AG017649-05, K24 AG000949, R01 AG020253, R21 AG025193-02, R03 AG029861, R01AG17649, R01 AG017649, R01 AG029656, R21AG025193, R01 AG020253-03, K24 AG000949-08, R01 AG018772-04, R03AG029861, R03 AG029861-01A1, R01AG018772-04, R01AG20253] Funding Source: Medline
- NIGMS NIH HHS [K08 GM077057-03, KO8GM077057, K08 GM077057] Funding Source: Medline
The purpose of this analysis was to determine if postoperative delirium was associated with early postoperative cognitive dysfunction (at 7 days) and long-term postoperative cognitive dysfunction (at 3 months). The International Study of Postoperative Cognitive Dysfunction recruited 1218 subjects >= 60 years old undergoing elective, non-cardiac surgery. Postoperatively, subjects were evaluated for delirium using the criteria of the Diagnostic and Statistical Manual. Subjects underwent neuropsychological testing pre-operatively and postoperatively at 7 days (n = 1018) and 3 months (n = 946). Postoperative cognitive dysfunction was defined as a composite Z-score > 2 across tests or at least two individual test Z-scores > 2. Subjects with delirium were significantly less likely to participate in postoperative testing. Delirium was associated with an increased incidence of early postoperative cognitive dysfunction (adjusted risk ratio 1.6, 95% CI 1.1-2.1), but not long-term postoperative cognitive dysfunction (adjusted risk ratio 1.3, 95% CI 0.6-2.4). Delirium was associated with early postoperative cognitive dysfunction, but the relationship of delirium to long-term postoperative cognitive dysfunction remains unclear.
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