期刊
RESPIRATORY MEDICINE
卷 101, 期 10, 页码 2153-2159出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.rmed.2007.05.012
关键词
pressure; pulmonary artery; hypertension; pulmonary; pulmonary fibrosis; oximetry
资金
- NHLBI NIH HHS [U10 HL080411-03, R01 HL080206, U10 HL080411, HL080206, 5U10HL080411, 5P50HL67665, HL086491, P50 HL067665] Funding Source: Medline
Background: Reliable, noninvasive approaches to the diagnosis of pulmonary hypertension in idiopathic pulmonary fibrosis are needed. We tested the hypothesis that the forced vital capacity to diffusing capacity ratio and room air resting pulse oximetry may be combined to predict mean pulmonary artery pressure (MPAP) in idiopathic pulmonary fibrosis. Methods: Sixty-one idiopathic pulmonary fibrosis patients with available right-heart catheterization were studied. We regressed measured MPAP as a continuous variable on pulse oximetry (SpO(2)) and percent predicted forced vital capacity (FVC) to percent-predicted diffusing capacity ratio (% FVC/% DLCO) in a multivariable linear regression model. Results: Linear regression generated the following equation: MPAP = -11.9+0.272 x SPO2+0.0659 x (100-SPO2)(2)+3.06 x (% FVC/% DLCO); adjusted R-2 = 0.55, p < 0.0001. The sensitivity, specificity, positive predictive and negative predictive value of model-predicted pulmonary hypertension were 71% (95% confidence interval (Cl): 50-89%), 81% (95% CI: 68-92%), 71% (95% CI: 51-87%) and 81% (95% CI: 68-94%). Conclusions: A pulmonary hypertension predictor based on room air resting pulse oximetry and FVC to diffusing capacity ratio has a relatively high negative predictive value. However, this model will require external validation before it can be used in clinical practice. (C) 2007 Elsevier Ltd. All rights reserved.
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