期刊
INFECTION AND IMMUNITY
卷 75, 期 10, 页码 4799-4803出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.00738-07
关键词
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资金
- NIAID NIH HHS [R01 AI050618, AI-50618] Funding Source: Medline
Autophagy has been implicated In the intracellular destruction of Toxoplasma gondii by primed macrophages following gamma Interferon (IFN-gamma) activation of p47 GTPases. CD40 ligation has also been shown to trigger autophagic elimination of T. gondii Independent of IFN-gamma and p47 GTPases. Here we demonstrate that IFN-gamma/p47 GTPase-dependent elimination of T. gondii by strain CPS vaccine-primed macrophages Is independent of CD40/tumor necrosis factor signaling. Similar to wild-type controls, both CD40-deficient and tumor necrosis factor receptor 1/2 (TNFR1/2)-deficient macrophages can efficiently eliminate Invaded strain GFP-PTG and restrain its replication following priming. In contrast, macrophages from mice lacking the IFN-gamma receptor gene neither clear the parasites nor repress their proliferation. Thus, CD40 and IFN-gamma-induced pathogen elimination might represent two independent resistance pathways, the latter of which plays a primary role in anti-Toxoplasma immunity in mice.
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