期刊
FEBS LETTERS
卷 581, 期 24, 页码 4571-4576出版社
WILEY
DOI: 10.1016/j.febslet.2007.08.050
关键词
pVHL; kinesin-2; microtubules; primary cilium
Synthesis and maintenance of primary cilia are regulated by the von Hippel-Lindau (VHL) tumour suppressor protein. Recent studies indicate that this regulation is linked to microtubule-dependent functions of pVHL such as orienting microtubule growth and increasing plus-end microtubule stability, however little is known how this occurs. We have identified the kinesin-2 motor complex, known to regulate cilia, as a novel and endogenous pVHL binding partner. The interaction with kinesin-2 facilitates pVHL binding to microtubules. These data suggest that microtubule-dependent functions of pVHL are influenced by kinesin-2. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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