期刊
BRITISH JOURNAL OF CANCER
卷 97, 期 7, 页码 1005-1008出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6603932
关键词
body mass index; cohort studies; liver cancer; meta-analysis; obesity; review
类别
Cohort studies of excess body weight and risk of liver cancer were identified for a meta-analysis by searching MEDLINE and EMBASE databases from 1966 to June 2007 and the reference lists of retrieved articles. Results from individual studies were combined using a random-effects model. We identified 11 cohort studies, of which seven on overweight (with a total of 5037 cases) and 10 on obesity (with 6042 cases) were suitable for meta-analysis. Compared with persons of normal weight, the summary relative risks of liver cancer were 1.17 (95% confidence interval (CI): 1.02 - 1.34) for those who were overweight and 1.89 (95% CI: 1.51 - 2.36) for those who were obese. This meta-analysis finds that excess body weight is associated with an increased risk of liver cancer.
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