期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 129, 期 39, 页码 11900-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja073936h
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资金
- NCI NIH HHS [P50 CA114747, R01 CA082214, U54 CA119367, 5R01 CA082214] Funding Source: Medline
We report here syntheses of bisdeoxycoelenterazine derivatives that show significantly improved kinetics of the bioluminescent reaction. All derivatives contain a protecting group at the carbonyl group of the imidazopyrazinone moiety that ensures slower light signal decay. The longer lasting light signal offers the possibility of real-time imaging of protein-protein interactions.
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