期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 361, 期 4, 页码 941-945出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2007.07.137
关键词
odorant receptor; homology modelling; receptor specificity; (-)citronellal
To test the hypothesis that olfactory receptors (ORs) recognize different molecular features of odor molecules termed odotypes, we studied receptor-ligand interactions of two human and two mouse ORs, recognizing (-)citronellal. Structurally similar receptors provide identical binding pockets (OLFR43, OR1A1, and OR1A2), and have comparable EC50 values. Other ORs with lower sequence identity bind (-)citronellal in a different way, leading to different EC50 values. (C) 2007 Elsevier Inc. All rights reserved.
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