期刊
AMERICAN JOURNAL OF ROENTGENOLOGY
卷 205, 期 2, 页码 242-250出版社
AMER ROENTGEN RAY SOC
DOI: 10.2214/AJR.14.13964
关键词
abdominal organs; bone marrow; normal apparent diffusion coefficient (ADC); sex and age; whole-body DWI
资金
- 5-year joint grant from Cancer Research UK [C2536/A10337]
- Engineering & Physical Sciences Research Council
- Medical Research Council
- Department of Health
- Cancer Research UK [10337, 16584] Funding Source: researchfish
- National Institute for Health Research [13/122/01] Funding Source: researchfish
OBJECTIVE. The objectives of this study were to define the range of apparent diffusion coefficients (ADCs) from whole-body DWI in normal abdominal organs and bone marrow, to identify ADC differences between sexes and changes occurring with age, and to evaluate the effect of the fat fraction (FF) on the ADC of normal liver parenchyma and bone marrow. MATERIALS AND METHODS. Fifty-one healthy volunteers (mean age = 38 years; age range = 23-68 years) underwent whole-body DWI using single-shot echo-planar imaging (b = 0, 150, 400, 750, and 1000 s/mm(2)). A two-point Dixon technique was used to evaluate the FF. Perfusion-sensitive ADCs, which we refer to as ADC(ALL), and perfusion-insensitive ADCs, which we refer to as ADC(HIGH), of the liver and renal parenchyma, spleen, pancreatic tail, and red and yellow bone marrow were calculated. The relationships between ADC and sex, age, and FF were examined. RESULTS. ADC(ALL) and ADC(HIGH) were significantly higher in female volunteers for the pancreatic tail (p = 0.046 and 0.008, respectively), red bone marrow (p = 0.029 and 0.001), and yellow bone marrow (p < 0.001 for both) but with considerable overlap. There were significant negative correlations between ADC(ALL) and ADC(HIGH) and age in the liver parenchyma (p = 0.008 and 0.01, respectively) and in the yellow bone marrow (p = 0.013 and 0.039) for all subjects. ADC(ALL) and ADC(HIGH) were also negatively correlated with FF in the liver parenchyma (p = 0.006 and 0.008, respectively) and in yellow bone marrow (p < 0.001 and p = 0.001) in all subjects. CONCLUSION. The ADCs of normal liver parenchyma and bone marrow change significantly with age. The ADCs of bone marrow in women are significantly higher than those of men and correlate strongly with FF. These effects may have an impact on image interpretation when using whole-body DWI to assess disease burden and treatment response.
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