Synthesis of enantiomerically pure cycloalkenols via combination strategy of enzyme-catalyzed reaction and RCM reaction

The preparation of three types of cyclic alkenols, (S)-2-cyclohexenol, (R)-2,5-dihydrobenzo[b]oxepin-5-ol, and (R)-5,6-dihydro-2H- benzo[b]oxocin-6-ol, has been accomplished in enantiomerically pure forms as model compounds using a combination of a lipase-catalyzed reaction and a ring closing olefin metathesis (RCM) reaction. (c) 2007 Elsevier Ltd. All rights reserved.