期刊
JOURNAL OF NEUROSCIENCE
卷 27, 期 41, 页码 10947-10956出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2603-07.2007
关键词
lateral amygdala; basal amygdala; fear conditioning; synaptic transmission; LTP; GluR1; GluR3
资金
- Wellcome Trust [087736] Funding Source: Medline
The AMPA receptor subunit glutamate receptor 1 (GluR1 or GluR-A) contributes to amygdala-dependent emotional learning. It remains unclear, however, to what extent different amygdala pathways depend on GluR1, or other AMPA receptor subunits, for proper synaptic transmission and plasticity, and whether GluR1-dependent long-term potentiation (LTP) is necessary for auditory and contextual fear conditioning. Here, we dissected the role of GluR1 and GluR3 (GluR-C) subunits in AMPA receptor-dependent amygdala LTP and fear conditioning using knock-out mice (GluR1(-/-) and GluR3(-/-)). We found that, whereas LTP at thalamic inputs to lateral amygdala (LA) projection neurons and at glutamatergic synapses in the basal amygdala was completely absent in GluR1(-/-) mice, both GluR1 and GluR3 contributed to LTP in the cortico-LA pathway. Because both auditory and contextual fear conditioning were selectively impaired in GluR1(-/-) but not GluR3(-/-) mice, we conclude that GluR1-dependent synaptic plasticity is the dominant form of LTP underlying the acquisition of auditory and contextual fear conditioning, and that plasticity in distinct amygdala pathways differentially contributes to aversive conditioning.
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