期刊
GENE
卷 401, 期 1-2, 页码 12-18出版社
ELSEVIER
DOI: 10.1016/j.gene.2007.06.016
关键词
meta-analysis; microarray; transcript profiling; expression profiling; bioinformatics; gene expression; gene annotation; aging
资金
- NHGRI NIH HHS [T32 HG000045] Funding Source: Medline
- NIA NIH HHS [R37 AG012712-09, R37 AG012712, R37-AG12712] Funding Source: Medline
Microarray profiling of gene expression is a powerful tool for discovery, but the ability to manage and compare the resulting data can be problematic. Biological, experimental, and technical variations between studies of the same phenotype/phenomena create substantial differences in results. The application of conventional meta-analysis to raw microarray data is complicated by differences in the type of microarray used, gene nomenclatures, species, and analytical methods. An alternative approach to combining multiple microarray studies is to compare the published gene lists which result from the investigators' analyses of the raw data, as implemented in Lists of Lists Annotated (LOLA: www.lola.gwu.edu) and L2L (depts.NNrashinLton.edu/121/). The present review considers both the potential value and the limitations of databasing and enabling the comparison of results from different microarray studies. Further, a major impediment to cross-study comparisons is the absence of a standard for reporting microarray study results. We propose a reporting standard: standard microarray results template (SMART), which will facilitate the integration of microarray studies. (c) 2007 Elsevier B.V All rights reserved.
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