期刊
ANAEROBE
卷 18, 期 4, 页码 417-420出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.anaerobe.2012.04.002
关键词
Probiotics; Adhesion; Lactobacillus casei ATCC 393; Rats
类别
Adhesion to the intestine represents a critical parameter for probiotic action. In this study, the adhesion ability of Lactobacillus casei ATCC 393 to the gastrointestinal tract of Wistar rats was examined after single and daily administration of fermented milk containing either free or immobilized cells on apple pieces. The adhesion of the probiotic cells at the large intestine (cecum and colon) was recorded at levels >= 6 logCFU/g (suggested minimum levels for conferring a probiotic effect) following daily administration for 7 days by combining microbiological and strain-specific multiplex PCR analysis. Single dose administration resulted in slightly reduced counts (5 logCFU/g), while they were lower at the small intestine (duodenum, jejunum, ileum) (<= 3 logCFU/g), indicating that adhesion was a targeted process. Of note, the levels of L casei ATCC 393 were enhanced in the cecal and colon fluids both at single and daily administration of immobilized cells (6 and 7 logCFU/g, respectively). The adhesion of the GI tract was transient and thus daily consumption of probiotic products containing the specific strain is suggested as an important prerequisite for retaining its levels at an effective concentration. (C) 2012 Elsevier Ltd. All rights reserved.
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