期刊
JOURNAL OF PHYSIOLOGY-LONDON
卷 584, 期 2, 页码 509-519出版社
WILEY
DOI: 10.1113/jphysiol.2007.137679
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资金
- NIEHS NIH HHS [K22ES00359, K22 ES000359] Funding Source: Medline
- NINDS NIH HHS [R21 NS051536] Funding Source: Medline
N-methyl-D-aspartate receptor (NMDAR) activation can trigger both long- and short-term plasticity, promote cell survival, and initiate cell death. A number of studies suggest that the consequences of NMDAR activation can vary widely depending on whether synaptic or extrasynaptic receptors are activated. Here we have examined the spatial distribution of NMDARs of CAI pyramidal neurons in acutely dissected hippocampal slices. Using a physiological definition of extrasynaptic receptors as those not accessible to single release events, we find that extrasynaptic NMDARs comprise a substantial proportion of the dendritic NMDAR pool (36%). This pool of extrasynaplic NMDARs is stable and does not shuttle into the synaptic receptor pool, as we observe no recovery of synaptic current after MK-801 synaptic blockade and washout. The subunit composition of synaptic and extrasynaptic NMDA receptor pools is similar at 3 weeks of age, with NR213 subunits present in both compartments. NR213 receptors are not enriched in the extrasynaptic compartment. Our data suggest that any role played by extrasynaptic NMDARs in synaptic transmission is dictated by their subcellular location rather than their subunit composition (or mobility.
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