期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 17, 期 20, 页码 5683-5685出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.07.049
关键词
4-quinolyl isothiocyanate; 7-chloroquinolinyl thioureas; Plasmodium falciparum; human adenocarcinoma of the cervix
New 7-chloroquinolinyl thiourea derivatives derived from the corresponding 4,7-dichloroquinoline isothiocyanate were synthesized and evaluated for in vitro antimalarial and anticancer activity. The most active compound from the series displayed an inhibitory IC50 value of 1.2 mu M against the D-10 strain of Plasniodium falciparum. Lack of cytotoxicity towards HeLa cells indicates selectivity towards parasites. (c) 2007 Elsevier Ltd. All rights reserved.
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