期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 102, 期 3, 页码 549-559出版社
WILEY
DOI: 10.1002/jcb.21494
关键词
ETS; transcriptional regulation; breast cancer; microenvironment; proteome
资金
- NCI NIH HHS [P01 CA78582] Funding Source: Medline
ETS factors are members of one of the largest families of evolutionarily conserved transcription factors, regulating critical functions in normal cell homeostasis, that when perturbed contribute to tumor progression. The well docunnented alterations in ETS factor expression and function during breast cancer progression result in pleiotropic effects manifested by the downstream effect on their tat-get genes. Multiple ETS factors bind to the same regulatory sites present on target genes, suggesting redundant or competitive functions. Furthermore, additional events contribute to, or may be necessary for, target gene regulation. in order to advance our understanding of the ETS-dependent regulation of breast cancer progression and metastasis, this prospect article puts forward a model for examining the effects of simultaneous expression of multiple transcription factors on the transcriptome of non-metastatic and metastatic breast cancer. Compared to existing RNA profiles defined following expression of individual transcription factors, the anti- and prometastatic signatures obtained by examining specific ETS regulatory networks will significantly improve our ability to accurately predict tumor progression and advance our understanding of gene regulation in cancer. Coordination of multiple ETS gene functions also mediates interactions between tumor and stromal cells and thus contributes to the cancer phenotype. As such, these new insights I nay provide a novel view of the ETS gene family as well as a focal point for studying the complex biological control involved in tumor progression.
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