期刊
BLOOD
卷 110, 期 8, 页码 2955-2964出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2006-10-054726
关键词
-
类别
资金
- Medical Research Council [G0501838] Funding Source: researchfish
- MRC [G0501838] Funding Source: UKRI
- Medical Research Council [G0501838] Funding Source: Medline
The molecular pathways regulating lymphoid priming, fate, and development of multipotent bone marrow (BM) stem/ progenitor cells that continuously replace thymic progenitors remain largely unknown. Herein, we show that fms-like tyrosine kinase 3 (Flt3) figand (FI)-deficient mice have distinct reductions in the earliest thymic progenitors in fetal, postnatal, and adult thymus. A critical role of FL in thymopoiesis was particularly evident in the absence of interleukin-7 receptor alpha (IL-7R alpha) signaling. FI-/-II-7r(-/-) mice have extensive reductions in fetal and postnatal thymic progenitors that result in a loss of active thymopoiesis in adult mice, demonstrating an indispensable role of FL in IL-7R alpha independent fetal and adult T lymphopoiesis. Moreover, we establish a unique and critical role of FL, distinct from that of IL-7R alpha, in regulation of the earliest lineage-negative (Lin(-)) Lin(-)SCA1(+)KIT(+) (LSK) FLT3(hi) lymphoid primed multipotent progenitors in BM, demonstrating a key role of FLT3 signaling in regulating the very earliest stages of lymphoid progenitors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据