期刊
JOURNAL OF NEUROSCIENCE METHODS
卷 166, 期 1, 页码 1-12出版社
ELSEVIER
DOI: 10.1016/j.jneumeth.2007.05.013
关键词
cochlear implant; electrode; neural prosthesis; electrical stimulation; drug delivery; neurotrophin
资金
- NIDCD NIH HHS [N01-DC-2-1006, N01 DC021006, N01 DC3-1006, N01-DC-3-1006, N01 DC2-1006] Funding Source: Medline
- OLAO NIH HHS [HHSN263200700054C] Funding Source: Medline
The effectiveness of multichannel cochlear implants depends on the activation of perceptually distinct regions of the auditory nerve. Increased information transfer is possible as the number of channels and dynamic range are increased and electrical and neural interaction among channels is reduced. Human and animal studies have demonstrated that specific design features of the intracochlear electrode directly affect these performance factors. These features include the geometry, size, and orientation of the stimulating sites, proximity of the device to spiral ganglion neurons, shape and position of the insulating carrier, and the stimulation mode (monopolar, bipolar, etc.). Animal studies to directly measure the effects of changes in electrode design are currently constrained by the lack of available electrodes that model contemporary clinical devices. This report presents methods to design and fabricate species-specific customizable electrode arrays. We have successfully implanted these arrays in guinea pigs and cats for periods of Lip to 14 months and have conducted acute electrophysiological experiments in these animals. Modifications enabling long-term intracochlear drug infusion are also described. Studies using these scale model arrays will improve our understanding of how these devices function in human subjects and how we can best optimize future cochlear implants. (C) 2007 Elsevier B.V. All rights reserved.
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