期刊
ANAEROBE
卷 14, 期 3, 页码 161-165出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.anaerobe.2008.02.004
关键词
antimicrobial susceptibility; anaerobic bacteria; E-test; ATB-ANA; agar dilution
类别
A total of 60 anaerobic strains were isolated from 322 clinical specimens. These isolates were tested for susceptibility to seven antibiotics (penicillin G, amoxicillin/clavulanic acid, cefoxitin, imipenem, chloramphenicol, metronidazole, clindamycin) by using ATB-ANA and Epsilometer test (E-test) strips and the results were compared with the gold standard agar dilution method. Imipenem was found as the most effective agent in vitro among the agents tested (100%). Susceptibility to penicillin G, amoxicillin/clavulanic acid, cefoxitin, chloramphenicol, metronidazole and clindamycin are 36.7%, 83.3%, 88.3%,96.6%, 85% and 90%, respectively. E-test has showed a good correlation (r = 0.62, p = 0.001) statistically with the results of agar dilution (total agreement for all antibiotics changing between 90.01% and 98.45%) and a moderate correlation (r = 0.45, p = 0.048) with the results of ATB-ANA method (total agreement for all antibiotics changing between 75.46% and 98.76%). However, the routine use of agar dilution procedure is concluded to be cumbersome, whereas E-test method offers a reliable alternative. (C) 2008 Elsevier Ltd. All rights reserved.
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