期刊
TETRAHEDRON LETTERS
卷 48, 期 43, 页码 7571-7573出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2007.08.131
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A method for the synthesis of 3,3-disubstituted oxindole derivatives is described. This involves the base-mediated addition of malonate esters to 3-halo-3-alkyloxindoles. The addition is tolerant of a range of alkyl substituents at position 3 of the oxindole. Addition to an aryl chloro-oxindole is also described. (C) 2007 Elsevier Ltd. All rights reserved.
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