期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 104, 期 43, 页码 17198-17203出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0707585104
关键词
abstinence; addiction; amygdala; deprivation; stress
资金
- NIDDK NIH HHS [P01 DK026741, DK 26741] Funding Source: Medline
Nicotine, the main psychoactive ingredient of tobacco, induces negative emotional symptoms during abstinence that contribute to a profound craving for nicotine. However, the neurobiological mechanisms underlying how nicotine produces dependence remains poorly understood. We demonstrate one mechanism for both the anxiety-like symptoms of withdrawal and excessive nicotine intake observed after abstinence, through recruitment of the extra hypothalamic stress peptide corticotropin-releasing factor (CRF) system and activation of CRF, receptors. Overactivation of the CRF-CRF1 system may contribute to nicotine dependence and may represent a prominent target for investigating the vulnerability to tobacco addiction.
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