期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 104, 期 43, 页码 17046-17051出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0610928104
关键词
VDJ recombination; DNA-dependent protein kinase
资金
- NIAID NIH HHS [AI 048758, R01 AI048758] Funding Source: Medline
Two major DNA repair pathways, nonhomologous end-joining (NHEJ) and homologous recombination (HR), repair double- stranded DNA breaks (DSBs) in all eukaryotes. Additionally, several alternative end-joining pathways (or subpathways) have been reported that characteristically use short-sequence homologies at the DNA ends to facilitate joining. How a cell chooses which DNA repair pathway to use (at any particular DSB) is a central and largely unanswered question. For one type of DSB, there is apparently no choice. DSBs mediated by the lymphocyte-specific recombination activating gene (RAG) endonuclease are repaired virtually exclusively by NHEJ. Here we demonstrate that non-RAG-mediated DSBs can be similarly forced into the NHEJ pathway by physical association with the RAG endonuclease.
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