期刊
JOURNAL OF NEUROSCIENCE
卷 27, 期 43, 页码 11496-11500出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2213-07.2007
关键词
schizophrenia; glutamate; GABA; ensemble unit recording; antipsychotic drugs; metabotropic glutamate receptors
资金
- NIMH NIH HHS [R37 MH048404-20W1, R37 MH048404] Funding Source: Medline
NMDA receptors mediate excitatory postsynaptic potentials throughout the brain but, paradoxically, NMDA receptor antagonists produce cortical excitation in humans and behaving rodents. To elucidate a mechanism for these diverging effects, we examined the effect of use-dependent inhibition of NMDA receptors on the spontaneous activity of putative GABA interneurons and pyramidal neurons in the prefrontal cortex of awake rats. We find that inhibition of NMDA receptors predominately decreases the activity of putative GABA interneurons but, at a delayed rate, increases the firing rate of the majority of pyramidal neurons. Thus, NMDA receptors preferentially drive the activity of cortical inhibitory interneurons suggesting that NMDA receptor inhibition causes cortical excitation by disinhibition of pyramidal neurons. These findings support the hypothesis that NMDA receptor hypofunction, which has been implicated in the pathophysiology of schizophrenia, diminishes the inhibitory control of PFC output neurons. Reducing this effect may be critical for treatment of schizophrenia.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据