期刊
ORGANIC LETTERS
卷 9, 期 22, 页码 4483-4486出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol7018778
关键词
-
资金
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [748555] Funding Source: National Science Foundation
- NCRR NIH HHS [1 P20 RR16457] Funding Source: Medline
[GRAPHICS] Four classes of phosphitylating reagents were subjected to reactions with aminomethyl polystyrene resin-bound p-acetoxybenzyl alcohol to yield the corresponding polymer-bound mono-, di-, tri-, and tetraphosphitylating reagents. The solid-phase reagents were reacted with unprotected nucleosides (e.g., thymidine, adenosine, 3'-azido-3'-deoxythymidine, cytidine, or inosine) in the presence of 5-(ethylthio)-1H-tetrazole. Polymerbound nucleosides underwent oxidation with tert-butyl hydroperoxide, deprotection of cyanoethoxy groups with DBU, and the acidic cleavage, respectively, to afford 5',5'-dinucleoside mono-, di-, tri-, and tetraphosphodiesters in 59-78% yield.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据