期刊
NEUROREPORT
卷 18, 期 16, 页码 1729-1733出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e3282f0d3f4
关键词
axotomy; cell body response; conditioning lesion; dorsal root ganglion; galanin; neuropeptide; sciatic nerve; sensory neuron
资金
- Medical Research Council [G0300028] Funding Source: researchfish
- MRC [G0300028] Funding Source: UKRI
- Medical Research Council [G0300028] Funding Source: Medline
- NEI NIH HHS [EY11373] Funding Source: Medline
- NINDS NIH HHS [NS17512] Funding Source: Medline
Sensory neurons show enhanced neurite outgrowth in vivo and in vitro following a conditioning lesion. Previous studies have shown that these effects are dependent on two members of the gp130 family of cytokines, leukemia inhibitory factor and interleukin-6. Here, we asked whether galanin, a neuropeptide induced by these cytokines, plays a role in the conditioning lesion response. Following a conditioning lesion, neurite outgrowth in culture was reduced in sensory neurons from galanin -/- mice compared with those from wild type controls. In neurons from wild type mice, the length of the longest neurite was increased 2.4-fold after a conditioning lesion, compared with 1.8-fold in neurons from knockout animals. The results indicate that the induction of galanin plays an important role in triggering the conditioning lesion response. (C) 2007 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据