期刊
EXPERIMENTAL AND MOLECULAR MEDICINE
卷 39, 期 5, 页码 565-573出版社
KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY
DOI: 10.1038/emm.2007.62
关键词
genome; human; hyperkalemia; hypertension; neoplasms; protein kinases; pseudohypoaldosteronisms; WNK1 protein; human
资金
- NIDDK NIH HHS [DK59530, DK54368] Funding Source: Medline
- NIGMS NIH HHS [GM53032] Funding Source: Medline
WNKs (with-no-lysine [K]) are a family of serine-threonine protein kinases with an atypical placement of the catalytic lysine relative to all other protein kinases. The roles of WNK kinases in regulating ion transport were first revealed by the findings that mutations of two members cause a genetic hypertension and hyper-kalemia syndrome. More recent studies suggest that WNKs are pleiotropic protein kinases with important roles in many cell processes in addition to ion transport. Here, we review roles of WNK kinases in the regulation of ion balance, cell signaling, survival, and proliferation, and embryonic organ development.
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