期刊
AMYOTROPHIC LATERAL SCLEROSIS
卷 13, 期 5, 页码 459-464出版社
INFORMA HEALTHCARE
DOI: 10.3109/17482968.2012.700938
关键词
Amyotrophic lateral sclerosis; motor neuron disease; season of birth; weather; early development
资金
- Aimee Stacey Memorial Bequest
- Burnett Bequest
- Motor Neuron Disease Research Institute of Australia
- Swedish Research Council
- Australian National Health and Medical Research Council
- Hjarnfonden
- Svenska Sallskapet for Medicinsk Forskning (SSMF)
Studies in the northern hemisphere suggest that the numbers of amyotrophic lateral sclerosis (ALS) births vary depending on the season of the year. We wished to determine if a southern hemisphere study would show the same seasonal changes, and whether particular weather conditions were associated with the numbers of ALS births. Birth data from a case-control study of Australian residents were used to relate monthly birth rates of ALS to the seasons and weather conditions. The results were compared with previous studies in Japan, Sweden and Switzerland. Four hundred and ninety-one Australian sporadic ALS patients and 629 controls (partners, friends, and community volunteers) completed a self-reported questionnaire that included dates of birth. Australian ALS birth rates increased between late summer and early winter, and decreased between mid-winter and early summer. Similar patterns were seen in Japan and Sweden. Monthly average humidity correlated positively with the numbers of ALS births in Australia, Sweden, and Japan. In conclusion, seasonal differences in ALS birth rates in the southern hemisphere are similar to those in two out of three northern hemisphere countries. Early life factors related to weather conditions, such as increased humidity leading to more infectious diseases and allergens, need to be further investigated in ALS.
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