期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 17, 期 21, 页码 5772-5776出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.08.056
关键词
antibacterial activity; immobilization; beta-sheet; antimicrobial peptide; conjugation; resin
We synthesized a novel peptide-resin conjugate by immobilizing beta-sheet antibacterial peptide on PEG-PS resin. The peptide-resin conjugate, similar to cationic antimicrobial peptides, demonstrated unique properties such as potent antibacterial activity, no hemolytic activity, lipid membrane perturbation activity, and potent synergism with vancomycin. Specially, the peptide-resin conjugate showed a more increased lipid membrane perturbation activity in comparison to unbound beta-sheet antibacterial peptide. (c) 2007 Elsevier Ltd. All rights reserved.
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