期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 17, 期 21, 页码 5853-5857出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.08.030
关键词
dipeptidyl peptidase IV inhibitors; diabetes; glucagon-like; peptide-1 (GLP-1); incretin hormones; imidazopiperidine amides
A series of substituted imidazopiperidine amides has been prepared and evaluated for inhibition of dipeptidyl peptidase IV (PP-4). Substitution at the 1- and 3-positions produced increased selectivity for DPP-4 relative to DPP-8 and DPP-9. Compounds in this series had IC50 values as low as 5.8 nM for inhibition of DPP-4. Published by Elsevier Ltd.
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