期刊
BRAIN BEHAVIOR AND IMMUNITY
卷 21, 期 8, 页码 1000-1008出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2007.06.015
关键词
psychosocial; stress; development; conditioning; psychoneuroimmunology; sickness behavior; cytokines; SES
资金
- NCRR NIH HHS [M01 RR003186, M01 RR003186-190423] Funding Source: Medline
- NIAAA NIH HHS [AA013973] Funding Source: Medline
- NIAID NIH HHS [AI067518, R01 AI067518-04, R01 AI067518] Funding Source: Medline
- NIA NIH HHS [AG008768, AG011915, P01 AG020166, P01 AG020166-069003, AG20166] Funding Source: Medline
- NICHD NIH HHS [HD39386] Funding Source: Medline
- NIMH NIH HHS [MH37373, P50 MH061083-050002, R01 MH037373, P50 MH061083] Funding Source: Medline
Studies investigating the influence of psychosocial factors on immunity played a critical and formative role in the field of psychoneuroimmunology (PNI), and have been a major component of articles published in Brain, Behavior and Immunity (BBI). An analysis of papers during the first two decades of BBI from 1987-2006 revealed three behavior-related topics were most prominent: (1) stress-induced changes in immune responses, (2) immune correlates of psychopathology and personality, and (3) behavioral conditioning of immunity. Important subthemes included the effect of early rearing conditions on immune maturation in the developing infant and.. subsequently.. psychosocial influences affecting the decline of immunity in the senescent host. The responsiveness of cell functioning in the young and elderly helped to validate the view that our immune competence is malleable. Many technical advances in immune methods were also evident. Initially, there was a greater reliance on in vitro proliferative and cytolytic assays, while later studies were more likely to use cell subset enumerations, cytokine quantification, and indices of latent virus reactivation. The reach of PNI extended from the traditional clinical entities of infection, autoimmunity, and cancer to attain a broader relevance to inflammatory physiology, and thus to asthma, cardiovascular and gastrointestinal disease. There continue to be many theoretical and applied ramifications of these seminal findings. Fortunately, the initial controversies about whether psychological processes could really impinge upon and modify immune responses have now receded into the pages of history under the weight of the empirical evidence. (C) 2007 Elsevier Inc. All rights reserved.
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