期刊
SEMINARS IN IMMUNOPATHOLOGY
卷 29, 期 4, 页码 337-353出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-007-0092-1
关键词
B cell; systemic lupus erythematosus; lupus nephritis; glomerulonephritis; autoimmunity; autoantibodies; immune complex; antigen presentation; tolerance
The production of pathogenic antibody has been traditionally viewed as the principle contribution of B cells to the pathogenesis of immune-mediated glomerulonephritis. However, it is increasingly appreciated that B cells play a much broader role in such diseases, functioning as antigen-presenting cells, regulators of T cells, dendritic cells, and macrophages and orchestrators of local lymphatic expansion. In this review, we provide an overview of basic B cell biology and consider the evidence implicating B cells in one of the archetypal immune-mediated glomerulonephritides, lupus nephritis.
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