期刊
NATURE METHODS
卷 4, 期 11, 页码 927-929出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH1112
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资金
- NHLBI NIH HHS [5 T32 HL007708] Funding Source: Medline
- NIGMS NIH HHS [GM56169] Funding Source: Medline
- NINDS NIH HHS [NS28471] Funding Source: Medline
G protein-coupled receptors (GPCRs) constitute the largest family of signaling proteins in mammals, mediating responses to hormones, neurotransmitters, and senses of sight, smell and taste. Mechanistic insight into GPCR signal transduction is limited by a paucity of high-resolution structural information. We describe the generation of a monoclonal antibody that recognizes the third intracellular loop (IL3) of the native human beta(2) adrenergic (b2AR) receptor; this antibody was critical for acquiring diffraction-quality crystals.
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