期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 35, 期 -, 页码 1191-1194出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0351191
关键词
enterciendocrine cell; G-protein-coupled receptor (GPCR); gut hormone; intestinal glucose sensing; sodium/glucose co-transporter 1 (SGLT1); taste receptor
资金
- NIDCD NIH HHS [R01 DC003155, R01 DC003055] Funding Source: Medline
SGLT1 (Na+/glucose co-transporter 1) transports the dietary sugars, D-glucose and D-galactose, from the lumen of the intestine into enterocytes. SGLT1 regulation has important consequences for the provision of glucose to the respiring tissues and is therefore essential for maintaining glucose homoeostasis. SGLT1 expression is directly regulated in response to changes in the sugar content of the diet. To monitor these variations, there is a requirement for a glucose-sensing system located on the luminal membrane of gut cells. This short review focuses on recent findings on intestinal sugar sensing and the downstream mechanisms responsible for enhancement in SGLT1 expression.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据