期刊
NATURE METHODS
卷 4, 期 11, 页码 903-905出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH1111
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资金
- NHGRI NIH HHS [U54 HG 003273, R21HG004553] Funding Source: Medline
We applied high-density microarrays to the enrichment of specific sequences from the human genome for high-throughput sequencing. After capture of 6,726 approximately 500-base 'exon' segments, and of 'locus-specific' regions ranging in size from 200 kb to 5 Mb, followed by sequencing on a 454 Life Sciences FLX sequencer, most sequence reads represented selection targets. These direct selection methods supersede multiplex PCR for the large-scale analysis of genomic regions.
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