期刊
AMINO ACIDS
卷 46, 期 6, 页码 1419-1439出版社
SPRINGER WIEN
DOI: 10.1007/s00726-014-1710-6
关键词
Amino acid network; Network properties; Software tools; Protein structure and function
资金
- National Natural Science Foundation of China [31170795, 91230117, 91029703]
- Specialized Research Fund for the Doctoral Program of Higher Education of China [20113201110015]
- International S&T Cooperation Program of Suzhou [SH201120]
- National High Technology Research and Development Program of China (863 program) [2012AA02A601]
Amino acid networks (AANs) are undirected networks consisting of amino acid residues and their interactions in three-dimensional protein structures. The analysis of AANs provides novel insight into protein science, and several common amino acid network properties have revealed diverse classes of proteins. In this review, we first summarize methods for the construction and characterization of AANs. We then compare software tools for the construction and analysis of AANs. Finally, we review the application of AANs for understanding protein structure and function, including the identification of functional residues, the prediction of protein folding, analyzing protein stability and protein-protein interactions, and for understanding communication within and between proteins.
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