期刊
AMINO ACIDS
卷 47, 期 10, 页码 2037-2063出版社
SPRINGER WIEN
DOI: 10.1007/s00726-014-1765-4
关键词
Glutamine; Leucine; Rapamycin; Lysosomes; Mitochondria
资金
- INSERM
- CNRS
- University Paris Descartes
- ANR
- INCa
- University Paris-Sud
Amino acids not only participate in intermediary metabolism but also stimulate insulin-mechanistic target of rapamycin (MTOR)-mediated signal transduction which controls the major metabolic pathways. Among these is the pathway of autophagy which takes care of the degradation of long-lived proteins and of the elimination of damaged or functionally redundant organelles. Proper functioning of this process is essential for cell survival. Dysregulation of autophagy has been implicated in the etiology of several pathologies. The history of the studies on the interrelationship between amino acids, MTOR signaling and autophagy is the subject of this review. The mechanisms responsible for the stimulation of MTOR-mediated signaling, and the inhibition of autophagy, by amino acids have been studied intensively in the past but are still not completely clarified. Recent developments in this field are discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据