期刊
AMINO ACIDS
卷 47, 期 2, 页码 429-434出版社
SPRINGER WIEN
DOI: 10.1007/s00726-014-1890-0
关键词
Sodium channel; Post-translational modification; Arginine methylation; Phosphorylation; Cross-talk
资金
- Fundacio Obra Social La Caixa, Spanish Government [SAF2011-27627, CTQ2011-25086/BQU)]
- European Community [PCIG14-GA-2013-630978]
Arginine methylation is a novel post-translational modification within the voltage-gated ion channel superfamily, including the cardiac sodium channel, Na(V)1.5. We show that Na(V)1.5 R513 methylation decreases S516 phosphorylation rate by 4 orders of magnitude, the first evidence of protein kinase A inhibition by arginine methylation. Reciprocally, S516 phosphorylation blocks R513 methylation. Na(V)1.5 p.G514C, associated to cardiac conduction disease, abrogates R513 methylation, while leaving S516 phosphorylation rate unchanged. This is the first report of methylation-phosphorylation cross-talk of a cardiac ion channel.
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