期刊
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
卷 6, 期 6, 页码 391-398出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s10237-006-0059-5
关键词
-
资金
- Intramural NIH HHS [Z01 AG000811] Funding Source: Medline
- NIAMS NIH HHS [AR45989, R01 AR045989, R01 AR045989-09] Funding Source: Medline
- NIA NIH HHS [R01 AG017021, R01 AG013087, AG13087, AG00811, AG17021] Funding Source: Medline
An early response to mechanical stimulation of bone cells in vitro is an increase in intracellular calcium concentration ([Ca2+](i)). This study analyzed the [Ca2+](i) wave area, magnitude, duration, rise time, fall time, and time to onset in individual osteoblasts for two identical bouts of mechanical stimulation separated by a 30-min rest period. The area under the [Ca2+](i) wave increased in the second loading bout compared to the first. This suggests that rest periods may potentiate mechanically induced intracellular calcium signals. Furthermore, many of the [Ca2+](i) wave parameters were strongly positively correlated between the two bouts of mechanical stimulation. For example, in individual primary osteoblasts, if a cell had a large [Ca2+](i) wave area in the first bout it was likely to have a large [Ca2+](i) wave area in the second bout (r(2) = 0.933). These findings support the idea that individual bone cells have calcium fingerprints (i.e., a unique [Ca2+](i) wave profile that is reproducible for repeated exposure to a given stimulus).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据