期刊
CLINICS IN DERMATOLOGY
卷 25, 期 6, 页码 574-580出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.clindermatol.2007.08.012
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Psoriasis is a T cell-dependent autoimmune disease of the skin and joints. Disease manifestation is orchestrated by proinflammatory CD4-positive T helper cells producing either interferon-gamma (Th1) or interleukin (IL)-17 (Th17). These Th1 and TH17 cells interact with dermal dendritic cells, macrophages, mast cells, and neutrophils. Together, they cause an inflammation that mainly involves interferon- gamma, tumor necrosis factor, IL-8, IL-12, IL-17, IL-19, and IL-23. New therapeutics either are directed against T cells, tumor necrosis factor, and IL-12/IL-23 or deviate immune responses into a protective IL-4-dominated Th2 phenotype. (c) 2007 Elsevier Inc. All rights reserved.
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