期刊
AMINO ACIDS
卷 44, 期 5, 页码 1267-1277出版社
SPRINGER WIEN
DOI: 10.1007/s00726-013-1468-2
关键词
Siderophore; Iron uptake; Iron homeostasis; TonB-dependent transporters; ABC transporters
资金
- Centre National de la Recherche Scientifique
- Centre International de Recherche au Frontiere de la Chimie (FRC)
- ANR (Agence Nationale de Recherche) [ANR-08-BLAN-0309-02]
- Association Vaincre la Mucoviscidose
- Agence Nationale de la Recherche (ANR) [ANR-08-BLAN-0309] Funding Source: Agence Nationale de la Recherche (ANR)
Siderophore production and utilization is one of the major strategies deployed by bacteria to get access to iron, a key nutrient for bacterial growth. The biological function of siderophores is to solubilize iron in the bacterial environment and to shuttle it back to the cytoplasm of the microorganisms. This uptake process for Gram-negative species involves TonB-dependent transporters for translocation across the outer membranes. In Escherichia coli and many other Gram-negative bacteria, ABC transporters associated with periplasmic binding proteins import ferrisiderophores across cytoplasmic membranes. Recent data reveal that in some siderophore pathways, this step can also be carried out by proton-motive force-dependent permeases, for example the ferrichrome and ferripyochelin pathways in Pseudomonas aeruginosa. Iron is then released from the siderophores in the bacterial cytoplasm by different enzymatic mechanisms depending on the nature of the siderophore. Another strategy has been reported for the pyoverdine pathway in P. aeruginosa: iron is released from the siderophore in the periplasm and only siderophore-free iron is transported into the cytoplasm by an ABC transporter having two atypical periplasmic binding proteins. This review presents recent findings concerning both ferrisiderophore and siderophore-free iron transport across bacterial cytoplasmic membranes and considers current knowledge about the mechanisms involved in iron release from siderophores.
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