期刊
AMINO ACIDS
卷 45, 期 4, 页码 937-945出版社
SPRINGER WIEN
DOI: 10.1007/s00726-013-1547-4
关键词
PPL; Promiscuity; Bis(indolyl)alkanes; Cascade reaction
资金
- National Natural Science Foundation of China [21072172, 21272208]
- Zhejiang Provincial Natural Science Foundation [2010-Z4090225]
A cascade reaction between aldehydes and indole catalyzed by lipase from porcine pancreas Type II (PPL) in solvent mixture at 50 A degrees C was reported for the first time. Some control experiments had been designed to demonstrate that the PPL was responsible for the cascade reaction. After the optimization of the stepwise process, a series of bis(indolyl)alkanes were prepared in moderate to excellent yields under the catalysis of PPL.
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