期刊
JOURNAL OF FOOD ENGINEERING
卷 83, 期 1, 页码 31-40出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jfoodeng.2006.11.001
关键词
bioactive carrier; beta-lactoglobulin; controlled release; encapsulation; hydrogel; nanoparticle; swelling ratio; whey protein
Whey proteins can be used as hydrogels and nanoparticle systems for encapsulation and controlled delivery of bioactive compounds. Whey protein concentrate (WPC) hydrogels exhibited pH-sensitive swelling behavior with minimum swelling ratio near the isoelectric point (pI) of whey proteins (similar to 5.1). The controlled drug release behavior of WPC hydrogels was studied using caffeine as a model drug. Consistent with the swelling behavior, the release of encapsulated model drug from the hydrogels was slower when the pH was below pI than it was at pH above pI The swelling and release behavior of the WPC hydrogels can be changed easily with different layers of alginate coating. Nanoparticles of about 60 mn average particle size were prepared with beta-lacto globulin (BLG) using a desolvation method by preheating the BLG solution to 60 degrees C. The stability of the particles was investigated by degradation experiments at neutral and acidic conditions with and without proteolytic enzyme. (c) 2006 Elsevier Ltd. All rights reserved.
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