OBJECTIVES Techniques for laparoscopic radical cystectomy are rapidly evolving. The entire procedure can be performed completely intracorporeally by pure laparoscopic techniques or by open-assisted laparoscopic techniques in which the urinary diversion is constructed extracorporeally by way of a minilaparotomy incision. We retrospectively evaluated the outcomes of these two techniques with a focus on perioperative outcomes and associated morbidity. METHODS From December 1999 to March 2006, 54 patients underwent laparoscopic radical cystectomy for muscle invasive (n = 35) or high-risk non-muscle-invasive (n = 19) bladder cancer. The mean follow-up was 25 months (range, 1 to 66 months). RESULTS Of the 54 patients, 17 underwent a pure laparoscopic (group 1, 8 conduit and 9 neobladder) and 37 underwent an open-assisted laparoscopic (group 2, 18 conduit and 19 neobladder) procedure. No significant differences were noted between the groups in patient age, comorbidities, or pathologic stage of malignancy. Group 2 was superior with regard to operative time, blood toss, transfusion rate, time to oral intake, time to ambulation, and postoperative complications (P <0.05 for all comparisons). Anastomotic leak, bowel obstruction, or sepsis requiring reexploration developed in 5 patients (29%) in group I and 4 patients (11%) in group 2. A learning curve was observed for both procedures, but it was particularly steep for the pure laparoscopic technique, and this approach was eventually abandoned. CONCLUSIONS Laparoscopic radical cystectomy is associated with a learning curve, with morbidity largely resulting from the urinary diversion procedure. Our experience suggests that the open-assisted laparoscopic approach is technically more efficient and associated with a quicker recovery profile and decreased complication rates compared with the pure laparoscopic approach. UROLOGY 70: 910-915, 2007. (c) 2007 Elsevier Inc.
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