期刊
WIENER KLINISCHE WOCHENSCHRIFT
卷 119, 期 19-20, 页码 564-569出版社
SPRINGER WIEN
DOI: 10.1007/s00508-007-0878-0
关键词
hypergastrinemia; Zollinger-Ellison syndrome; chronic atrophic gastritis; type A gastritis
The most frequent conditions of hypergastrinemia in man are the Zollinger-Ellison syndrome with autonomous gastrin hypersecretion by the tumour cell and reactive hypergastrinemia in type A autoimmune chronic atrophic gastritis with achlorhydria causing unrestrained gastrin release from the gastrin-producing antral G-cells. Both entities differ with respect to the pH in the gastric fluid, which is < 2 in patients with Zollinger-Ellison syndrome and neutral in type A gastritis. Other conditions with moderate hypergastrinemia as treatment with proton pump inhibitors, gastric outlet obstruction, previous vagotomy, chronic renal failure or short bowel syndrome are of minor clinical importance.
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