期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 27, 期 11, 页码 1792-1797出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.jcbfm.9600474
关键词
bacterial meningitis; hydrogen peroxide; streptococcus pneumoniae; vasodilation
Alterations of blood flow contribute to major clinical complications in invasive infections such as sepsis and bacterial meningitis. As a unique feature streptococci - in particular, Streptococcus pneumoniae, the most frequent pathogen in bacterial meningitis - release hydrogen peroxide ( H2O2) because of the absence of functional catalase. In a 6 h rat model of experimental meningitis, we studied the impact of bacterial H2O2 production on regional cerebral blood flow ( rCBF) and intracranial pressure (ICP). Compared to wild- type D39 pneumococci, the increase of rCBF was diminished in meningitis induced by the H2O2 defective SpxB- mutant ( maximum increase, 135% +/- 17% versus 217% +/- 23% of the individual baseline; P< 0.01) or after treatment of D39- induced meningitis with H2O2- degrading catalase or with tetraethylammonium ( TEA), a blocker of calciumsensitive potassium channels, which mediate H2O2- induced vasodilation. Catalase did not significantly reduce the remaining rCBF increase caused by SpxB-, supporting the predominant role of bacterial H2O2. We conclude that in addition to host- sided mediators, bacterial- derived H2O2 acts as a potent vasodilator, which accounts for a certain proportion of the early cerebral hyperperfusion in pneumococcal meningitis.
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