Extraordinary metabolic stability of peptides containing α-aminoxy acids

The metabolic stability of peptides containing a mixed sequence of alpha-aminoxy acids and alpha-amino acids is significantly improved compared to peptides composed of only natural alpha-amino acids. The introduction of an alpha-aminoxy acid into peptide chain dramatically improves the stability of the amide bonds immediately before and after it. These peptides containing alpha-aminoxy acids represent excellent structural scaffold for the design of metabolically stable and biologically active peptides.