期刊
AMINO ACIDS
卷 43, 期 1, 页码 499-503出版社
SPRINGER WIEN
DOI: 10.1007/s00726-011-1095-8
关键词
Metabolism; Peptides; Stability; Aminoxy acid
资金
- Hong Kong Research Grants Council (HKU)
The metabolic stability of peptides containing a mixed sequence of alpha-aminoxy acids and alpha-amino acids is significantly improved compared to peptides composed of only natural alpha-amino acids. The introduction of an alpha-aminoxy acid into peptide chain dramatically improves the stability of the amide bonds immediately before and after it. These peptides containing alpha-aminoxy acids represent excellent structural scaffold for the design of metabolically stable and biologically active peptides.
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